modafinil will reduce the extent or influence of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

In animal scientific tests, the median lethal dose (LD50) of modafinil varies among the species and is dependent upon the route of administration. In mice and rats, the LD50 is close to 1250 mg/kg if administered by using an injection, however the oral LD50 for rats is 3400 mg/kg.

This medication is offered only with your medical doctor's prescription. This products is offered in the subsequent dosage forms:

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apalutamide will lessen the extent or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medications which have been CYP3A4 substrates may end up in lessen exposure to those medications.

Medicines that have restrictions apart from prior authorization, amount boundaries, and step therapy affiliated with Every single prescription.

This is the most popular dosage utilized for cognitive enhancement. It concerns no shock this is likewise the most typical dosage kind identified on the web.

Reassess degree of sleepiness regularly; if utilized adjunctively with steady good airway stress (CPAP): Periodic assessment of CPAP compliance is necessary

Modafinil and armodafinil had been researched like a complement to antipsychotic drugs inside the therapy of schizophrenia. They showed no click here effect on good signs or cognitive functionality.[243][244] A 2015 meta-Investigation located that modafinil and armodafinil may well a little reduce adverse indicators in those with acute schizophrenia, nevertheless they do not look valuable for those with the ailment who are stable, with substantial destructive symptom scores.

Absorption: Modafinil is instantly absorbed after oral administration. It is insoluble within an aqueous Remedy and therefore can't be administered intravenously. Highest plasma focus is achieved 2-four hours soon after administration. 

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Steer clear of or substitute One more drug for these drugs when attainable. Appraise for loss of therapeutic result if medication has to be coadministered.

Modafinil is often an incredibly helpful medication to boost your workflow and productivity. Men and women generally utilize it to obtain a stage ahead of their colleagues or Competitiveness and to spice up their Total effectiveness at get the job done or university.

Prevent or Use Alternate Drug. Steer clear of coadministration of delicate CYP3A4 substrates with ivosidenib or switch with substitute therapies. If coadministration is unavoidable, watch patients for loss of therapeutic result of such medicines.